In contemporary society, vampires inhabit the Earth and are considered humanity's greatest adversaries. However, a substitute for human blood has been discovered, allowing vampires to consume it with effects equivalent to that of human blood. This product is known as True Blood. Consequently, humans and vampires have the opportunity to coexist peacefully and even engage in relationships. Nonetheless, rogue factions from both groups remain poised to disrupt this fragile peace.
Although vampires have existed for centuries, they have only recently revealed their existence to the public, integrating into everyday life. Sookie Stackhouse, a telepathic waitress from a small town in Louisiana, experiences a dramatic shift in her life when she meets Bill, her first vampire, and develops feelings for him. The series chronicles Sookie's many escapades involving humans, vampires, and eventually other supernatural entities, exposing her to the reality that not everything and everyone is as they appear.
The narrative centers around Sookie Stackhouse (Anna Paquin), a barmaid in Louisiana with the ability to read minds, and how her life dramatically changes when the vampire Bill Compton (Stephen Moyer) enters her workplace, two years after vampires publicly disclosed their existence on national television.